Abstract

Objective: The aim of this research was to evaluate bone regeneration capacity of a mixture of Fibrin glue and Xenogeneic bone graft versus a mixture of BMAC, Fibrin glue and Xenogeneic bone in critical sized periapical bone defects. Materials and methods: Sixteen patients randomly and equally divided into two groups; Group I: eight patients with critical periapical bone defects were grafted by a mixture of fibrin glue and xenograft. Group II: eight patients with critical periapical bone defects were grafted by a mixture of BMAC, fibrin glue and xenograft. Assessment of pain was done on a Visual Analogue Scale (VAS) immediate, 3 days and 1 week post-operatively. Radiographic evaluation: for the bone density, volumetric changes and defect dimensions measurement between study groups. Results: the highest mean score on visual analogue scale was found in (Group I), while the lowest mean score was found in (Group II). Group (II) experienced a significant positive change in defect dimensions, in bone density and defect volume which increase by time in bone density over group (I) till the end of our follow up time which is 6 months. Conclusion: MSCs present in BMAC promote bone regeneration and improve the density of regenerated bone.

Keywords:

bone marrow aspirate concentrate, fibrin glue, critical bone defect, xenograft, bone regeneration.

• Received: 27 August 2024
• Accepted:  19  September 2024
• Published: 27 September 2024